Description: Our Lady of Perpetual Help is a Roman Catholic title of the Blessed Virgin Mary associated with a 15th-century Byzantine icon with an alleged Marian apparition. The icon is believed to have originated from the Keras Kardiotissas Monastery and has been in Rome since 1499. Today it is permanently enshrined in the Church of Saint Alphonse of Liguori, where the official Novena to Our Mother of Perpetual Help text is prayed weekly.

Pope Pius IX granted a Pontifical decree of Canonical Coronation along with its present title on 5 May 1866.